A novel approach to gene silencing through discrete targeting of gene regulators using site specific nucleases.
Applications: Silencing gene expression in order to monitor cellular processes and host/pathogen interactions.
Intellectual Property: Patents pending
Technology Field: Pharmaceuticals, Biotechnology
Business Opportunity: Investment for further technology development
Technology Description: This invention relates to a single cell assay to silence gene expression through the discrete targeting of gene regulatory.Major regulatory elements include; (I) enhancers, (II) sites within chromatin loops that engage in intra- or interchromosomal contact in multigene complexes and (III) regulatory sites within chromatin loops that determine loop structure.
Benefits & Advantages: Site specific and very targeted gene silencing
Inventors: Dr Musa Mhlanga Dr Stephanie Fanucchi Yotaro Shibayama Shaun Christopher Burd