Measuring cellular response to infection using novel reporter markers.
Applications: Measuring cellular response to infection using novel reporter markers
Intellectual Property: Patents pending
Technology Field: Biotechnology
Business Opportunity: Investment for further technology development and conduct relevant trials
Technology Description: Monitoring the cellular response to infection using a fluorescent reporter, single molecule FISH and immunofluorescent labeling, revealed that HIV1 masks DNA damage and orchestrates a complex dysregulation of lincRNAp21. By sequestering HuR in the nucleus following proviral integration, HIV1 enables lincRNAp21 degradation.
Benefits & Advantages: very specific report model to measure response to infection at a cellualar level
Inventors: Dr Janine Scholefield Dr Musa Mhlanga Jerolen Naidoo Dr Sam Barichievy